PUBLICATIONS  

2023

Efe G, Dunbar KJ, Sugiura K, Cunningham K, Carcamo S, Karaiskos S, Tang Q, Cruz-Acuña R, Resnick-Silverman L, Peura J, Lu C, Hasson D, Klein-Szanto AJ, Taylor AM, Manfredi JJ, Prives C, Rustgi AK. p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression. Cancer Discov. 2023 Dec 12;13(12):2632-2651. doi: 10.1158/2159-8290.CD-23-0601. PMID: 37676642.

Chibaya L, Lusi CF, DeMarco KD, Kane GI, Brassil ML, Parikh CN, Murphy KC, Li J, Naylor TE, Cerrutti J, Peura J, Pitarresi JR, Zhu LJ, Fitzgerald KA, Atukorale PU, Ruscetti M. Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer. bioRxiv [Preprint]. 2023 Sep 18:2023.09.18.558307. doi: 10.1101/2023.09.18.558307. PMID: 37790484; PMCID: PMC10542133.

Pitarresi JR, Stanger BZ. Cellular Origins and Lineage Plasticity in Cancer. Cold Spring Harb Perspect Med. 2023 Aug 21:a041389. doi: 10.1101/cshperspect.a041389. Epub ahead of print. PMID: 37604590.

Fernandez Garcia E, Paudel U, Noji MC, Bowman CE, Rustgi AK, Pitarresi JR, Wellen KE, Arany Z, Weissenrieder JS, Foskett JK. The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation. Front Cell Dev Biol. 2023 Jun 8;11:1082213. doi: 10.3389/fcell.2023.1082213. PMID: 37363724; PMCID: PMC10285664.

Perez K, Chiarella AM, Cleary JM, Horick N, Weekes C, Abrams T, Blaszkowsky L, Enzinger P, Giannakis M, Goyal L, Meyerhardt JA, Rubinson D, Yurgelun MB, Goessling W, Giantonio BJ, Brais L, Germon V, Stonely D, Raghavan S, Bakir B, Das K, Pitarresi JR, Aguirre AJ, Needle M, Rustgi AK, Wolpin BM. Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer. Oncologist. 2023 May 8;28(5):425-432. doi: 10.1093/oncolo/oyad002. PMID: 36807743; PMCID: PMC10166179.

McBrearty N, Cho C, Chen J, Zahedi F, Peck AR, Radaelli E, Assenmacher CA, Pavlak C, Devine A, Yu P, Lu Z, Zhang H, Li J, Pitarresi JR, Astsaturov I, Cukierman E, Rustgi AK, Stanger BZ, Rui H, Fuchs SY. Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells. Mol Cancer Res. 2023 Mar 1;21(3):228-239. doi: 10.1158/1541-7786.MCR-22-0602. PMID: 36378658.

2022

Barry-Hundeyin M, Carrot-Zhang J, Dayton T, Ghazanfar S, Guenther LM, Nguyen DTT, Pitarresi JR, Rajput S, Santana-Codina N, Shree T, Zeng Z, Zhang Y. The 2022 generation. Nat Cancer. 2022 Dec;3(12):1426-1431. doi: 10.1038/s43018-022-00481-z. PMID: 36539504.

STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer. Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE 3rd, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC. Life Sci Alliance. 2022 Jul 8;5(11):e202201460. doi: 10.26508/lsa.202201460. Print 2022 Nov.PMID: 35803738

2021

Patient-derived organoids as a platform for modeling a patient's response to chemoradiotherapy in esophageal cancer. Karakasheva TA, Gabre JT, Sachdeva UM, Cruz-Acuña R, Lin EW, DeMarshall M, Falk GW, Ginsberg GG, Yang Z, Kim MM, Diffenderfer ES, Pitarresi JR, Li J, Muir AB, Hamilton KE, Nakagawa H, Bass AJ, Rustgi AK. Sci Rep. 2021 Oct 29;11(1):21304. doi: 10.1038/s41598-021-00706-8.PMID: 34716381

MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma. Maddipati R, Norgard RJ, Baslan T, Rathi KS, Zhang A, Saeid A, Higashihara T, Wu F, Kumar A, Annamalai V, Bhattacharya S, Raman P, Adkisson CA, Pitarresi JR, Wengyn MD, Yamazoe T, Li J, Balli D, LaRiviere MJ, Ngo TC, Folkert IW, Millstein ID, Bermeo J, Carpenter EL, McAuliffe JC, Oktay MH, Brekken RA, Lowe SW, Iacobuzio-Donahue CA, Notta F, Stanger BZ. Cancer Discov. 2022 Feb;12(2):542-561. doi: 10.1158/2159-8290.CD-20-1826. Epub 2021 Sep 22.PMID: 34551968

Single-cell analysis of ductal differentiation. Pitarresi JR, Rustgi AK.Nat Biomed Eng. 2021 Aug;5(8):785-786. doi: 10.1038/s41551-021-00782-1.PMID: 34389821

Calcium signaling induces a partial EMT. Norgard RJ*, Pitarresi JR*, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ. EMBO Rep. 2021 Sep 6;22(9):e51872. doi: 10.15252/embr.202051872. Epub 2021 Jul 29.PMID: 34324787 (co-first)

Pancreatic plasticity: Unlocking exocrine lineage specification. Pitarresi JR, Rustgi AK. Cell Stem Cell. 2021 Jun 3;28(6):987-988. doi: 10.1016/j.stem.2021.05.006.PMID: 34087158

Mutant p53 regulates Survivin to foster lung metastasis. Tang Q, Efe G, Chiarella AM, Leung J, Chen M, Yamazoe T, Su Z, Pitarresi JR, Li J, Islam M, Karakasheva T, Klein-Szanto AJ, Pan S, Hu J, Natsugoe S, Gu W, Stanger BZ, Wong KK, Diehl JA, Bass AJ, Nakagawa H, Murphy ME, Rustgi AK.Genes Dev. 2021 Apr 1;35(7-8):528-541. doi: 10.1101/gad.340505.120. Epub 2021 Mar 18.PMID: 33737385

PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability. Pitarresi JR, Norgard RJ, Chiarella AM, Suzuki K, Bakir B, Sahu V, Li J, Zhao J, Marchand B, Wengyn MD, Hsieh A, Kim IK, Zhang A, Sellin K, Lee V, Takano S, Miyahara Y, Ohtsuka M, Maitra A, Notta F, Kremer R, Stanger BZ, Rustgi AK. Cancer Discov. 2021 Jul;11(7):1774-1791. doi: 10.1158/2159-8290.CD-20-1098. Epub 2021 Feb 15.PMID: 33589425

2020

Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. Hsieh A, Pitarresi JR, Lerner J, Donahue G, Hsiehchen D, Rustgi AK, Zaret K.Sci Adv. 2020 Dec 4;6(49):eabc4517. doi: 10.1126/sciadv.abc4517. Print 2020 Dec.PMID: 33277249

EMT, MET, Plasticity, and Tumor Metastasis. Bakir B*, Chiarella AM*, Pitarresi JR*, Rustgi AK. Trends Cell Biol. 2020 Oct;30(10):764-776. doi: 10.1016/j.tcb.2020.07.003. Epub 2020 Aug 13.PMID: 32800658 (*co-first)

Pharmacologic Activation of the G Protein-Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma. Natale CA, Li J, Pitarresi JR, Norgard RJ, Dentchev T, Capell BC, Seykora JT, Stanger BZ, Ridky TW. Cell Mol Gastroenterol Hepatol. 2020;10(4):868-880.e1. doi: 10.1016/j.jcmgh.2020.04.016. Epub 2020 May 4.PMID: 32376419

2019

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains. Park D, Shakya R, Koivisto C, Pitarresi JR, Szabolcs M, Kladney R, Hadjis A, Mace TA, Ludwig T. PLoS One. 2019 Dec 26;14(12):e0226714. doi: 10.1371/journal.pone.0226714. eCollection 2019.PMID: 31877165

Mechanisms Underlying Metastatic Pancreatic Cancer. Pitarresi JR, Rustgi AK.Adv Exp Med Biol. 2019;1164:3-10. doi: 10.1007/978-3-030-22254-3_1.PMID: 31576536

PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells. Marchand B, Pitarresi JR, Reichert M, Suzuki K, Laczkó D, Rustgi AK.Oncogene. 2019 May;38(22):4325-4339. doi: 10.1038/s41388-019-0725-6. Epub 2019 Jan 31.PMID: 30705403

2018

Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth. Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE 3rd, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC. Life Sci Alliance. 2018 Oct 26;1(5):e201800190. doi: 10.26508/lsa.201800190. eCollection 2018 Oct.PMID: 30456390

The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine. Chatterji P, Hamilton KE, Liang S, Andres SF, Wijeratne HRS, Mizuno R, Simon LA, Hicks PD, Foley SW, Pitarresi JR, Klein-Szanto AJ, Mah AT, Van Landeghem L, Gregory BD, Lengner CJ, Madison BB, Shah P, Rustgi AK. Genes Dev. 2018 Aug 1;32(15-16):1020-1034. doi: 10.1101/gad.314369.118.PMID: 30068703

Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK.Dev Cell. 2018 Jun 18;45(6):696-711.e8. doi: 10.1016/j.devcel.2018.05.025.PMID: 29920275

ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis. Das KK, Heeg S, Pitarresi JR, Reichert M, Bakir B, Takano S, Kopp JL, Wahl-Feuerstein A, Hicks P, Sander M, Rustgi AK.Dev Dyn. 2018 Jun;247(6):854-866. doi: 10.1002/dvdy.24626. Epub 2018 Apr 19.PMID: 29532564

2017

Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele. Wu J, Liu X, Nayak SG, Pitarresi JR, Cuitiño MC, Yu L, Hildreth BE 3rd, Thies KA, Schilling DJ, Fernandez SA, Leone G, Ostrowski MC. PLoS One. 2017 Sep 21;12(9):e0184984. doi: 10.1371/journal.pone.0184984. eCollection 2017.PMID: 28934293

IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB. Victor AR, Nalin AP, Dong W, McClory S, Wei M, Mao C, Kladney RD, Youssef Y, Chan WK, Briercheck EL, Hughes T, Scoville SD, Pitarresi JR, Chen C, Manz S, Wu LC, Zhang J, Ostrowski MC, Freud AG, Leone GW, Caligiuri MA, Yu J. J Immunol. 2017 Oct 1;199(7):2333-2342. doi: 10.4049/jimmunol.1601554. Epub 2017 Aug 25.PMID: 28842466

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration. Giroux V, Lento AA, Islam M, Pitarresi JR, Kharbanda A, Hamilton KE, Whelan KA, Long A, Rhoades B, Tang Q, Nakagawa H, Lengner CJ, Bass AJ, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi AK. J Clin Invest. 2017 Jun 1;127(6):2378-2391. doi: 10.1172/JCI88941. Epub 2017 May 8.PMID: 28481227

The ETS family of oncogenic transcription factors in solid tumours. Sizemore GM, Pitarresi JR, Balakrishnan S, Ostrowski MC. Nat Rev Cancer. 2017 Jun;17(6):337-351. doi: 10.1038/nrc.2017.20. Epub 2017 Apr 28.PMID: 28450705

2016

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E, Cruz-Monserrate Z, Yu L, Young G, Zhong X, Zimmers TA, Ostrowski MC, Ludwig T, Bloomston M, Bekaii-Saab T, Lesinski GB. Gut. 2018 Feb;67(2):320-332. doi: 10.1136/gutjnl-2016-311585. Epub 2016 Oct 21.PMID: 27797936

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia. Pitarresi JR*, Liu X*, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC. Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006.PMID: 27659014 (*co-first)

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Liu X*, Pitarresi JR*, Cuitiño MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G, Wu J, Ostrowski MC. Genes Dev. 2016 Sep 1;30(17):1943-55. doi: 10.1101/gad.283499.116. Epub 2016 Sep 15.PMID: 27633013 (*co-first)

2011-2015

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.Mace TA, Shakya R, Elnaggar O, Wilson K, Komar HM, Yang J, Pitarresi JR, Young GS, Ostrowski MC, Ludwig T, Bekaii-Saab T, Bloomston M, Lesinski GB. Oncotarget. 2015 Dec 29;6(42):44509-22. doi: 10.18632/oncotarget.6332.PMID: 26575024

Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis. Wallace JA*, Pitarresi JR*, Sharma N, Palettas M, Cuitiño MC, Sizemore ST, Yu L, Sanderlin A, Rosol TJ, Mehta KD, Sizemore GM, Ostrowski MC. Front Oncol. 2014 Apr 23;4:87. doi: 10.3389/fonc.2014.00087. eCollection 2014.PMID: 24795864 (co-first).

Prabhu V, Srivastava P, Yadav N, Amadori M, Schneider A, Seshadri A, Pitarresi J, Scott R, Zhang H, Koochekpour S, Gogada R, Chandra D. Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. Mitochondrion. 2013 Sep;13(5):493-9. doi: 10.1016/j.mito.2012.10.010. Epub 2012 Oct 23. PMID: 23088850; PMCID: PMC3567227.

Gogada R, Amadori M, Zhang H, Jones A, Verone A, Pitarresi J, Jandhyam S, Prabhu V, Black JD, Chandra D. Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis. Cell Cycle. 2011 Dec 1;10(23):4128-37. doi: 10.4161/cc.10.23.18292. Epub 2011 Dec 1. PMID: 22101335; PMCID: PMC3272293.